Review: sheer adrenaline keeps "Battleship" afloat

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Advanced Prostate Cancer Drug May Help at Earlier Stage

WEDNESDAY, May 16 (HealthDay News) -- A drug approved to treat advanced prostate cancer appears to help men who have localized high-risk prostate cancer if given before surgery.

Adding Zytiga (abiraterone) to conventional hormonal treatments eliminated or nearly eliminated the prostate cancer in one-third of men with this often-lethal form, according to new research to be presented at next month's annual meeting of the American Society of Clinical Oncology (ASCO) in Chicago.

"This is one of the first -- if not the first -- study to show that you can make prostate cancer in the prostate gland itself disappear in a reproducible number of patients," ASCO official Dr. Nicholas Vogelzang said at a Wednesday press conference.

Commenting on the findings, Dr. Jay Brooks, chairman of hematology/oncology at Ochsner Health System in Baton Rouge, said, "This is exciting. It's a novel way to eliminate cancer before surgery."

However, Brooks, who was not involved in the study, cautioned that the findings were still preliminary and need further investigation.

Trying to shrink a tumor with chemotherapy and/or radiation before surgery is standard for other types of cancer, such as breast or colon, but hasn't to date shown a benefit in prostate cancer, study author Dr. Mary-Ellen Taplin, associate professor of medicine at Harvard Medical School and Dana-Farber Cancer Institute in Boston, explained at the news conference.

Localized high-risk prostate cancer, which is defined as prostate cancer in men with a prostate-specific antigen level above 20, high-grade disease (a Gleason score of 8 or more), and stage T3 disease (indicating the tumor has spread through the prostate), carries with it a poor prognosis.

Standard hormonal therapy, which stops the production of male hormones (androgens), has not been shown to be effective in this type of cancer when given before surgery. Nor has the surgery, which removes the entire prostate.

Zytiga blocks production of testosterone, which can promote the growth of prostate cancer cells, but in a different way than established hormonal treatments.

This small, phase 2 trial involved 56 men with an average age of 58, all of whom had had at least three positive biopsies for prostate cancer.

For the first three months, 27 men received the standard hormonal therapy leuprolide alone, followed by leuprolide plus Zytiga for another three months.

The remaining 29 men received the two-drug combination for the whole six months, after which all men in both groups underwent prostate surgery.

One-third of the men who had received leuprolide plus Zytiga for the entire six months saw complete or nearly complete elimination of their cancer.

By comparison, only 15 percent of men in the other group experienced these results, the investigators found.

Those who received the combination for only 12 weeks had much lower response rates.

The participants also received low doses of the steroid prednisone to prevent side effects from Zytiga, although side effects overall were minimal, said Taplin.

It's not clear at this point why some men responded to the combination therapy while others did not, and that is an area that needs to be studied, the researchers said.

"In highly select people who have this aggressive type of prostate cancer, I think this is an important area to investigate," Brooks noted. "We need to figure out which patients would potentially benefit."

According to study author Taplin, the research received some funding from Johnson & Johnson, the maker of Zytiga. She said the drug is currently U.S. Food and Drug Administration-approved for patients with advanced prostate cancer that does not respond to hormone therapy, and costs about $5,000 per month.

The data and conclusions of research presented at medical meetings should be viewed as preliminary until published in a peer-reviewed journal.

More information

The U.S. National Cancer Institute has more on treatments for prostate cancer.

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'Survivor: One World' Post-Mortem: What Have We Learned?

MTV News teams up with former 'Survivor' player Rob Cesternino to cover Kim's win, Colton's controversy, the future of the game and more.
By Josh Wigler

Kim Spradlin
Photo: CBS

on Sunday, concluding with the rightful victory of bridal-shop owner Kim Spradlin. After running multiple alliances and winning four immunity challenges (among other accomplishments), Kim's status as one of the all-time greatest "Survivor" winners can't be denied. But even though the best player won the game, does that mean "One World" was one of the better seasons in "Survivor" history? Not necessarily — certainly not if you're asking season villain Colton Cumbie, who declared during the live "Survivor" reunion that "One World" got boring once he was medically evacuated from the game.

Did Kim deserve to win? Should she play again? Was Colton's assessment of a lackluster "Survivor" season on point? We tackled all of these questions and more in our final "One World" post-game with two-time contestant Rob Cesternino. Thanks for joining us all season long, Rob!

MTV: Kim Spradlin, your girl and mine, took home the win on Sunday night. I don't think anybody was surprised to see that happen, but I'm definitely happy with the outcome. I'm assuming you're pleased as well?

Rob Cesternino: I was very happy to see Kim win the game. I think she gave one of the most dominating performances ever by a "Survivor" player, and I think Kim is, from a historical "Survivor" perspective, the only true alpha female to have won the game. That's impressive.

MTV: You wouldn't put ['Fans vs. Favorites' winner] Parvati Shallow in that category?

Cesternino: Parvati is a bit of a different animal in that she used her sexuality to her advantage. I'm certainly not complaining about that — every "Survivor" player is different. But Kim didn't seduce Troyzan, or any of the guys, to get what she wanted and to get to the end. She used the same tactics that Boston Rob might use, or what any of the traditional male powerhouses would do to win the game. I think that was very interesting about Kim's performance.

Midway through the finale, when Kim got rid of Alicia and then decided to not bring Christina to the final three, I was yelling at the TV, "Kim, what are you doing? These people are so much easier to beat!" But then mid-sentence I realized, "You know what? It doesn't matter what she does. She's winning no matter what!" I think Kim felt like, "Why overthink this? I'm winning if I go with Chelsea and Sabrina. I'm winning if I go with Alicia and Christina. Why have a card that people can play against me — that I betrayed my true friends in the game?" Kim came to this realization about three episodes ago, I think. Her win was a fait accompli. Any other outcome would have been greatly unsatisfying.

MTV: Let's look back a bit. I don't imagine there's a lot that Colton ever said that you or I would agree with, with the possible exception of one comment he made at the finale: The season got boring once he left. Do you think that's fair? Was "One World" without Colton a bit of a bore?

Cesternino: I think it was. Colton, for all of the horrible things he was saying (which gave us plenty to talk about), was the pre-Kim mastermind of this season. He was the one sending the guys to tribal council. He was the one pulling all of the strings and going back to work with the women. So at least he was adding something to this season. When you lost him, a lot of people were just sheep to Kim for the rest of the season. That can be boring to watch.

MTV: Did you buy Colton's apology at the finale?

Cesternino: I follow Colton on Twitter, and I don't think he's changed at all from being on "Survivor." I think if he truly changed, I think you would have seen a much different person [at the finale] than the person who was on "Survivor." I mean, all Survivors say right after the show, "Oh my god, 'Survivor' changed me so much." I don't buy it. I don't think that "Survivor" really changes people. I think that true life-altering events change people, or time changes people. In the six months or whatever since they filmed this, I don't think Colton or any of the players in the game have truly changed.

MTV: Do you think we'll see him play again?

Cesternino: I thought Jeff Probst had said that Colton would never play again, but I've also read recently that he's softening that stance. I do think that Colton will play again, but probably not for a while. With these larger-than-life returning players, their best friend is time. Had Russell Hantz gone back on the show now as opposed to a season after "Heroes vs. Villains," I think he would have fared better in the game. Time is the friend of the high-profile "Survivor" player, because the more people who come onto the show, they don't really remember what [previous players] did. The best thing that happened to Russell was Colton. The best thing that will happen to Colton is Jimmy Hamburger or whoever the next "Survivor" villain is. That will make people forget about Colton.

MTV: Looking ahead to next season, Probst revealed that the twist for "Survivor Philippines" is that three formerly med-evaced players are coming back to the game. What do you think about that?

Cesternino: I think more so than those people returning to the game, I like the idea where they're going with [three] tribes of six people. When you look back at the past three or four seasons, people have made alliances of five on basically the first day of the game, and those five people have tended to be the final five, or at least five of the final six. The game is becoming a little too predictable, so it's time to shake things up a little bit so that on the first day you can't say "This is the five, we're going to be the final five." These players will have to adjust their plans and work with people on the other tribes to get to the end of the game.

MTV: I love the three-tribe format, which they've only done on "All-Stars." Then again, you might have a different opinion...

Cesternino: Well, I'm personally biased against the three-tribe system, since it didn't work out so well for me on "All-Stars." [Laughs] I do think it probably lends to a better overall game, but you can lose some good people early on if the right two or three people get together and call the shots on a six-person group.

MTV: Going back to the topic of returning players, the identities of these three former contestants are still under wraps. But I'm sure we'll see another "All-Stars" variation at some point in the future. Kim has certainly proven herself as an All-Star. When I spoke with Kim, she said she'd be up for returning. I know she told you the same thing in your interview with her. How do you think she'd do if she went back another time?

Cesternino: I think Kim would do very well on an "All-Stars" season. Here's the thing about Survivors: they don't necessarily target winners. They target who gets the most publicity and the most press. Russell isn't targeted because he's a two-time finalist; he's targeted because he gets the most air time. One of the biggest things that helped Sandra, who is a two-time winner, is that nobody thinks to get rid of her because she won; they'd get rid of Sandra if she dominated the air time, which never really happened. I bet she would do very well again. For Kim, it's the same situation. Survivors resent the people who get the most publicity and air time, and that's not necessarily Kim. I think she'd do well in an "All-Stars" season, because people wouldn't view her as that kind of a threat.

MTV: Let's wrap this up by looking at the season overall. What should the "Survivor" powers that be learn from "One World"? What lessons should they take away from this year?

Cesternino: That's a great question. [Pauses] I think what the "Survivor" powers that be need to learn the most is to really take a look at the people they're putting on the show, and making sure that everybody going out there is armed with at least the basic knowledge of how the game works. We're going into "Survivor 25." Every contestant needs at least a crash course in how alliances work, what to do if you're not in the bottom of the alliance. I wish we had more people who really knew how to play the game before going out there, and not people learning on the fly. You wouldn't throw people on "Jeopardy" or "Wheel of Fortune" if they don't know the rules of the game. Why are we putting people on "Survivor" who don't know the rules of the game thirteen years after it's been on the air?

Previously On MTV News' "Survivor" coverage:
» How the women dominated the game
» Why Kim deserved to win
» Kim Spradlin talks winning "One World"
» Our final "Survivor" predictions
» "Survivor: One World" gets Tarzaned

How do you feel about the latest "Survivor" season? Let us know in the comments section or hit me up on Twitter @roundhoward!

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?Debe Val?rie Trierweiler @ cerrar su Twitter? Es la pareja del presidente de Francia, Fran?ois Hollande about 2 hours ago via HootSuite

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Dog, nappy and football found in Aussie croc

Rangers who shot a saltwater crocodile that was terrorising pets in northern Australia found a dog, a pair of shorts, a football and a nappy in its stomach, a report said Wednesday.

Police notified authorities recently that a crocodile had eaten at least one dog and was lunging at others along a beach near the community of Galiwinku.

The Northern Territory News said rangers who went to the area Tuesday saw the 3.5 metre (11 feet 6 inches) croc grab a dog by the leg, and they shot it.

As well as finding the remains of a dog in its stomach, they discovered a variety of other items.

"While it might make a comical headline, it is disturbing to see the volume of rubbish in a wild animal," said the newspaper, which routinely runs crocodile stories on its front page.

Saltwater crocodiles, which can grow up to seven metres long and weigh more than a tonne, are a common feature of Australia's tropical north and kill an average of two people a year.

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LightSquared officially files for Chapter 11 bankruptcy

As expected, May 14th is indeed a dark day for LightSquared. The company has just filed paperwork in order to initiate Chapter 11 bankruptcy proceedings in Manhattan's US Bankruptcy Court, effectively killing its dream of providing a high-speed mobile wireless network to upwards of 260 million people. Not quite a year after Sprint and LightSquared put together an agreement that would ensure 15 years of blissful LTE enjoyment together, Philip Falcone's baby looks weaker than ever. With the Sprint tie-up now void, and over $1.6 billion in debt, there's probably not too many places for LS to turn. The primary hurdle -- one it never could seem to overcome -- was the FCC's outright refusal to believe any of the company's mitigation proposals in relation to GPS interference issues. Despite "profoundly disagreeing" and raising all sorts of chaos in an effort to get its way, LightSquared never did manage to convince the powers that mattered. Where it turns from here is anyone's guess, but it won't be a quiet fall from grace, we're surmising.

LightSquared officially files for Chapter 11 bankruptcy originally appeared on Engadget on Mon, 14 May 2012 14:24:00 EDT. Please see our terms for use of feeds.

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Microsoft Research's MirageTable brings some augmented reality to your tabletop

We got a look at a holographic telepresence project from Microsoft Research earlier this week, but that's far from the only Kinect-enhanced rig it's working on these days. This setup dubbed a MirageTable was also shown off at the Computer-Human Interaction conference in Austin, Texas this week, offering a glimpse of one possible future where two people can interact with virtual objects on a table as if they were sitting across from each other (or simply do so on their own). To make that happen, the setup relies on a ceiling-mounted 3D projector to display the images on a curved surface, while a Kinect on each end of the connection both captures the person's image and tracks their gaze to ensure images are displayed with the proper perspective. You can check it out in action after the break, although some of the effect is lost without 3D glasses.

Continue reading Microsoft Research's MirageTable brings some augmented reality to your tabletop

Microsoft Research's MirageTable brings some augmented reality to your tabletop originally appeared on Engadget on Sat, 12 May 2012 07:16:00 EDT. Please see our terms for use of feeds.

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Nokia Drive, Transport features revealed, not yet heading to a Lumia near you

Did you think the addition of offline maps was the end of the update road for Nokia Drive? That's simply not so. After previewing the planned 3.0 refresh for us at Mobile World Congress, it appears Espoo's drawing closer to a finalized version of the Windows Phone app, bringing with it the ability to learn driving habits, display real-time movement and traffic on the homescreen live tile, as well as allowing users to manually adjust routes. The Finnish company's Transport app will also be seeing a bump up to version 2.0, letting users see nearby transit options based on their location, transfers and scheduling for 87 countries, amongst other features. There's no word on precisely when Lumia owners can expect to see this one-two navigation punch hit their handsets, but we're guessing sooner rather than later.

Nokia Drive, Transport features revealed, not yet heading to a Lumia near you originally appeared on Engadget on Fri, 04 May 2012 23:44:00 EDT. Please see our terms for use of feeds.

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